To build the otb2zcfg utility you should run the following command: mkdir build cd build ccmake .. make To generate the zcfgs for the OTB Applications available, you should run the following: mkdir zcfgs cd zcfgs export ITK_AUTOLOAD_PATH=/your/path/to/otb/applications ../build/otb2zcfg cp *zcfg /location/to/your/cgi-bin This ITK_AUTOLOAD_PATH environment variable will be required in the [env] section of your main.cfg.